linopirdine dihydrochloride Search Results


linopirdine dihydrochloride  (Alomone Labs)
91
Alomone Labs linopirdine dihydrochloride
IH and IM currents are not required for persistent firing. A, Bath application of the specific IH blocker ZD7288 (10 μm) hyperpolarized L5 pyramidal cells. Symbols represent the mean ± SEM. B, Blockade of IH by ZD7288 eliminated the membrane potential sag evident in responses to hyperpolarizing current steps (top) but did not abolish persistent firing evoked by a depolarizing step (bottom, both representative of 5 of 5 cells tested). C, ZD7288 significantly reduced sag ratio. *p = 0.0257, T = 3.464, df = 4, paired t test; for details of sag ratio analysis, see Materials and Methods). ZD7288 did not block persistent firing in 5 of 5 cells tested (n.s., p = 1.00, Fisher's exact test). D, Blockade of IH by ZD7288 did not occlude the ability of Terf to abolish persistent firing (representative of 4 of 4 experiments). E, Attenuation of IM current with XE991 (10 μm) did not occlude persistent firing in CCh. F, + <t>Linopirdine</t> (30 μm), another M current blocker, also failed to abolish persistent firing. G, Plot of the increase in number of spikes evoked during the depolarizing step before and after + Linopirdine. **p = 0.0087, T = 4.797, df = 4. H, Plot of the increase in number of spikes with linopridine following CCh treatment. *p = 0.020, T = 7.024, df = 2. Both paired t tests.
Linopirdine Dihydrochloride, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/linopirdine+dihydrochloride/Linopirdine+dihydrochloride/pmc05761618-220-126-160
Average 91 stars, based on 1 article reviews
linopirdine dihydrochloride - by Bioz Stars, 2026-11
91/100 stars
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linopirdine dihydrochloride  (Tocris)
93
Tocris linopirdine dihydrochloride
IH and IM currents are not required for persistent firing. A, Bath application of the specific IH blocker ZD7288 (10 μm) hyperpolarized L5 pyramidal cells. Symbols represent the mean ± SEM. B, Blockade of IH by ZD7288 eliminated the membrane potential sag evident in responses to hyperpolarizing current steps (top) but did not abolish persistent firing evoked by a depolarizing step (bottom, both representative of 5 of 5 cells tested). C, ZD7288 significantly reduced sag ratio. *p = 0.0257, T = 3.464, df = 4, paired t test; for details of sag ratio analysis, see Materials and Methods). ZD7288 did not block persistent firing in 5 of 5 cells tested (n.s., p = 1.00, Fisher's exact test). D, Blockade of IH by ZD7288 did not occlude the ability of Terf to abolish persistent firing (representative of 4 of 4 experiments). E, Attenuation of IM current with XE991 (10 μm) did not occlude persistent firing in CCh. F, + <t>Linopirdine</t> (30 μm), another M current blocker, also failed to abolish persistent firing. G, Plot of the increase in number of spikes evoked during the depolarizing step before and after + Linopirdine. **p = 0.0087, T = 4.797, df = 4. H, Plot of the increase in number of spikes with linopridine following CCh treatment. *p = 0.020, T = 7.024, df = 2. Both paired t tests.
Linopirdine Dihydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/linopirdine+dihydrochloride/Linopirdine+dihydrochloride/pmc02684066-58-0-2
Average 93 stars, based on 1 article reviews
linopirdine dihydrochloride - by Bioz Stars, 2026-11
93/100 stars
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1 3 dihydro 1 phenyl 3 3 bis 4 pyridinylmethyl 2h indol2 one dihydrochloride  (Tocris)
93
Tocris 1 3 dihydro 1 phenyl 3 3 bis 4 pyridinylmethyl 2h indol2 one dihydrochloride
IH and IM currents are not required for persistent firing. A, Bath application of the specific IH blocker ZD7288 (10 μm) hyperpolarized L5 pyramidal cells. Symbols represent the mean ± SEM. B, Blockade of IH by ZD7288 eliminated the membrane potential sag evident in responses to hyperpolarizing current steps (top) but did not abolish persistent firing evoked by a depolarizing step (bottom, both representative of 5 of 5 cells tested). C, ZD7288 significantly reduced sag ratio. *p = 0.0257, T = 3.464, df = 4, paired t test; for details of sag ratio analysis, see Materials and Methods). ZD7288 did not block persistent firing in 5 of 5 cells tested (n.s., p = 1.00, Fisher's exact test). D, Blockade of IH by ZD7288 did not occlude the ability of Terf to abolish persistent firing (representative of 4 of 4 experiments). E, Attenuation of IM current with XE991 (10 μm) did not occlude persistent firing in CCh. F, + <t>Linopirdine</t> (30 μm), another M current blocker, also failed to abolish persistent firing. G, Plot of the increase in number of spikes evoked during the depolarizing step before and after + Linopirdine. **p = 0.0087, T = 4.797, df = 4. H, Plot of the increase in number of spikes with linopridine following CCh treatment. *p = 0.020, T = 7.024, df = 2. Both paired t tests.
1 3 Dihydro 1 Phenyl 3 3 Bis 4 Pyridinylmethyl 2h Indol2 One Dihydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/linopirdine+dihydrochloride/Linopirdine+dihydrochloride/pm33927636-70-1-18
Average 93 stars, based on 1 article reviews
1 3 dihydro 1 phenyl 3 3 bis 4 pyridinylmethyl 2h indol2 one dihydrochloride - by Bioz Stars, 2026-11
93/100 stars
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linopirdine dihydrochloride  (Aladdin Scientific Corporation)
N/A
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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linopirdine dihydrochloride  (Biosynth Carbosynth)
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linopirdine dihydrochloride  (TargetMol)
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linopirdine dihydrochloride  (Santa Cruz Biotechnology)
N/A
Linopirdine dihydrochloride acts as a blocker of Kv7 voltage-gated potassium channels (KCNQ); blocks KCNQ2+3/M-currents (IC50 = 4-7 μM) and KCNQ1 homomeric channels (IC50 = 8.9 μM). DuP 996 increases hippocampal ACh release and is a
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linopirdine dihydrochloride  (StressMarq)
N/A
KCNQ Channel Blocker
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linopirdine dihydrochloride  (BOC Sciences)
N/A
Linopirdine dihydrochloride is a blocker of KV7 voltage-gated potassium channels. It can block KV7.1 + 7.3 (KCNQ2 + 3) / M-currents with IC50 value from 4 to 7 μM and KV7.1 homomeric channels with IC50
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Image Search Results


IH and IM currents are not required for persistent firing. A, Bath application of the specific IH blocker ZD7288 (10 μm) hyperpolarized L5 pyramidal cells. Symbols represent the mean ± SEM. B, Blockade of IH by ZD7288 eliminated the membrane potential sag evident in responses to hyperpolarizing current steps (top) but did not abolish persistent firing evoked by a depolarizing step (bottom, both representative of 5 of 5 cells tested). C, ZD7288 significantly reduced sag ratio. *p = 0.0257, T = 3.464, df = 4, paired t test; for details of sag ratio analysis, see Materials and Methods). ZD7288 did not block persistent firing in 5 of 5 cells tested (n.s., p = 1.00, Fisher's exact test). D, Blockade of IH by ZD7288 did not occlude the ability of Terf to abolish persistent firing (representative of 4 of 4 experiments). E, Attenuation of IM current with XE991 (10 μm) did not occlude persistent firing in CCh. F, + Linopirdine (30 μm), another M current blocker, also failed to abolish persistent firing. G, Plot of the increase in number of spikes evoked during the depolarizing step before and after + Linopirdine. **p = 0.0087, T = 4.797, df = 4. H, Plot of the increase in number of spikes with linopridine following CCh treatment. *p = 0.020, T = 7.024, df = 2. Both paired t tests.

Journal: The Journal of Neuroscience

Article Title: Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells

doi: 10.1523/JNEUROSCI.1774-17.2017

Figure Lengend Snippet: IH and IM currents are not required for persistent firing. A, Bath application of the specific IH blocker ZD7288 (10 μm) hyperpolarized L5 pyramidal cells. Symbols represent the mean ± SEM. B, Blockade of IH by ZD7288 eliminated the membrane potential sag evident in responses to hyperpolarizing current steps (top) but did not abolish persistent firing evoked by a depolarizing step (bottom, both representative of 5 of 5 cells tested). C, ZD7288 significantly reduced sag ratio. *p = 0.0257, T = 3.464, df = 4, paired t test; for details of sag ratio analysis, see Materials and Methods). ZD7288 did not block persistent firing in 5 of 5 cells tested (n.s., p = 1.00, Fisher's exact test). D, Blockade of IH by ZD7288 did not occlude the ability of Terf to abolish persistent firing (representative of 4 of 4 experiments). E, Attenuation of IM current with XE991 (10 μm) did not occlude persistent firing in CCh. F, + Linopirdine (30 μm), another M current blocker, also failed to abolish persistent firing. G, Plot of the increase in number of spikes evoked during the depolarizing step before and after + Linopirdine. **p = 0.0087, T = 4.797, df = 4. H, Plot of the increase in number of spikes with linopridine following CCh treatment. *p = 0.020, T = 7.024, df = 2. Both paired t tests.

Article Snippet: Drugs used included the following: carbamoylcholine chloride [CCh (carbachol)] used at 2 μ m (10 μ m in one experiment) with 10 m m stock solutions of CCh in water were prepared each day; gabazine (SR 95531, used at 10 μ m ); 2,3-dihydroxy-6-nitro-7-sulfonyl-benzo[ f ]quinoxaline (NBQX; used at 10 μ m ); 4-aminopyridine (4-AP; used at 100 μ m and purchased from Sigma-Aldrich); tetraethylammonium (TEA; used at 1 m m and purchased from Sigma-Aldrich); ZD7288 (used at 10 μ m ); nimodipine (20 μ m ); d -APV (used at 10 μ m ); N -(3,4-difluorophenyl)- N′ -(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea (ML297 used at 0.67 μM); terfenadine (Terf; used at 10 μ m ); E-4031 dihydrochloride (used at 10 μ m ); fexofenadine (used 30 μ m ); linopirdine dihydrochloride (used at 30 μ m ); XE991 (used at 10 μ m ); pirenzepine dihydrochloride (used at 10 μ m ); and ErgToxin-1 (used at 50 n m ) was purchased from Alomone Labs and dissolved in ACSF.

Techniques: Blocking Assay